어저귀(Abutilon theophrasti Medicus)와 쑥부쟁이(Aster yomena Makino)의 성분연구

Abstract

Abutilon theophrasti Medicus (Malvaceae) is an annual plant, native to southern Asia, and is distributed throughout the world. It is commonly used to treat dysentery middle-ear infection, dull pain of joint, etc. In a continuation of phytochemical study on Abutilon theophrasti, eleven compounds: lupenone(1), lupeol(2), stigmasterol(3), β-sitosterol(4), 24-methylene-3, 4-seco-cycloart-4(28)-en-3-oic acid(5), 24-methylene-3, 4- seco-cycloart-4(28)-en-3-methyl ester(6), (+)-(1S,4R)-7-Hydroxycalamenene (7), Hibicuslide C(8) were isolated from the methylene chloride soluble fraction and isopropyl-β-glucopyranoside(9), Syringaresinol-4'-O-β-D- monoglucoside(10), rutin(11) were isolated from n-butanol soluble fraction by the repeated silica gel, RP-18 and MCI gel column chromatography. The chemical structures of compounds1-6 were determined on the basis of physicochemical properties and spectroscopic methods such as 1D and 2D NMR. It is first time that these compounds were isolated from this plant and compound 6 and 9 were obtained as natural products not as synthetics Aster yomena Makino (Asteraceae) is a perennial herb that is distributed throughout Korea and Japan. The whole plant is used in Korean traditional medicine for the treatment of bronchial asthma, inflammation, and cold. So far, none of phytochemical studies on this plant have been done yet. Therefore, the aerial parts of A.yomena were studied in our on going investigation on biologically active compounds from natural products and subsequently a new megastigmane palmitate, 5(13)-megastigmen-9-one-3β- palmitate(12), and a new oleanane-type triterpenoid, 3β,23,28-trihydroxy-12- oleanene-11-one(13), together with eleven known compounds, β-amyrin(14), erythrodiol(15), 3β,23,28-triololean-12-ene(16), Spinasterone(17), simiaren- ol(18), α-amyrin(19), Lupeol(2), 23-hydroxybetulin(20), phytol(21), 1β,4β- dihydroxyeudesman-11-ene(22), Apigenin(23), 3,7-dihydroxyhumula-4,8(15),10 (E)-triene(24), and 2,6-dihydroxyhumula-3(12),7(13),9(E)-triene(25), were isolated from the methylene chloride soluble fraction and 4-O-β-D- glucopyranoside-3-hydroxy methyl benzoate(26), Caffeic acid(27), Esculetin (28). isoquercitrin(29), Isorhamnetin-3-O-glucoside(30) were isolated from n-butanol soluble fraction by column chromatography. These compounds, 2, 14-30 were isolated from this plant for the first time.