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두경부 편평세포암에서 c-Met 단백 발현의 의의

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Author(s)
김준
Issued Date
2010
Keyword
c-Met|Ki-67|Head and neck squamous cell carcinoma|Prognosis
Abstract
Background and Objectives:Various tumor markers have been studied in an attempt to evaluate and decide the optimal treatment of the patients with head and neck squamous cell carcinoma(HNSCC). A nuclear antigen Ki-67 is a proliferative marker of tumor cells in all phases of cell cycle except G0. c-met gene, the tyrosine kinase receptor for hepatocyte growth factor(HGF), may play various roles in malignant transformation. The author evaluated the prognostic significance of Ki-67 and c-Met in surgical specimens of HNSCC to determine the relationship with the various clinicopathological characteristics.
Materials and Methods:Formalin-fixed paraffin-embedded surgical specimens were obtained from 54 patients with HNSCC. Ki-67 and c-Met expressions were analyzed by immunohistochemical staning and were compared with the clinicopathological characteristics such as, pathologic differentiation, tumor stage, clinical stage and lymph node metastasis.
Results:There was positive correlation of increased expression of Ki-67 with tumor stage and clinical stage, increased expression of c-Met with tumor stage, clinical stage, and nodal status. But there was no significant correlation between expression of Ki-67 and nodal status for the HNSCC. The expression of c-Met had a significant positive relationship with Ki-67 index (p< 0.05). Conclusion:Therefore, Ki-67 and c-Met are useful markers of tumor progression, aggressiveness and prognosis in HNSCC.
Alternative Title
The significance of c- Met expression in the head and neck squamous cell carcinoma neck squamous cell carcinoma
Alternative Author(s)
Kim Jun
Affiliation
조선대학교 대학원
Department
일반대학원 의학과
Advisor
도남용
Awarded Date
2010-08
Table Of Contents
표목차.................................................................................................................. i

도목차.................................................................................................................. ii

Abstract.............................................................................................................. 1

서론...................................................................................................................... 3

연구재료 및 방법.............................................................................................. 5

결과....................................................................................................................... 8

고찰....................................................................................................................... 11

결론....................................................................................................................... 15

참고문헌............................................................................................................... 16
Degree
Master
Publisher
조선대학교 대학원
Citation
김준. (2010). 두경부 편평세포암에서 c-Met 단백 발현의 의의.
Type
Dissertation
URI
https://oak.chosun.ac.kr/handle/2020.oak/8711
http://chosun.dcollection.net/common/orgView/200000240144
Appears in Collections:
General Graduate School > 3. Theses(Master)
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