건강검진 수진자에서 대사증후군과 비알콜성지방간 및 생활습관과의 연관성

Abstract

ABSTRACT

Association of Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease ＆ Life Style in Health Screening

Seo, Jeong-A Advisor : Prof. Lee, Cheol Gab, M.D., Ph.D. Department of Health Science, Graduate School of Chosun University

Objectives: The purpose of this study was to examine the modality of risk factor of metabolic syndrome, the characteristic of assessment of life habits and the connection between metabolic syndrome and nonalcoholic fatty liver and then present basic data for the prevention and improvement of metabolic syndrome and for the enhancement of efficiency of health check-ups. For this, the investigator carried out a questionnaire survey of health check-up subjects at a hospital in Gwangju and then examined a variety of items with them.

Methods: A total of 1150 adult males and females were included in this study from May 2008 to March 2009 at a health promotion center in Kyung-gi do. An ultrasonographic evaluation of abdomen was conducted to evaluate NAFLD. The diagnosis of the metabolic syndrome was assessed as defined by the NCEP ATP III while abdominal obesity was assessed according to Asia-Pacific guidelines.

Results: Of the 717 subjects (men 94, women 30), 124 were diagnosed with NAFLD by ultra sonogram. BMI, waist circumference, fasting blood sugar, triglyceride, HDL cholesterol and levels all affected NAFLD independently. The prevalence of metabolic syndrome was increased in mild (62.5%) and moderate (72.2%) NAFLD groups. When odd ratio (95% CI) for NAFLD group was compared to the contrast group, there was an increased risk of metabolic syndrome with odd ratio of 3.4 (95% CI, 6.2~10.2).

Conclusions: Health check-up subjects' prevalence of metabolic syndrome is significantly high, thus reflecting the trend of general population's increase of risk factor of metabolic syndrome in recent years. The potential of occurring metabolic syndrome in the group of nonalcoholic fatty liver is high by 3.4 times. In order to manage the risk factors of metabolic syndrome, therefore, it is necessary to assess and intervene in all the life habits and then develop and carry out a differentiated health improvement program based on a risk group-oriented management strategy. In addition, a comprehensive and systematic study on the risk factor of metabolic syndrome must be prospectively carried out in the future.

Key words: metabolic syndrome risk factors, life styles, non-alcoholic fatty liver disease, NCEP ATP-Ⅲ