위암 환자에 발생한 동시성과 이시성 암의 임상병리학적 특성

Abstract

Introduction: With the development of diagnostic techniques, synchronous and metachronous cancers in gastric cancer patients are increasingly found. Methods: 1048 Patients who diagnosed with gastric cancer in Chosun University Hospital from January 1998 to March 2008 were reviewed retrospectively. The clinicopathological features of gastric cancer patients with synchronous and metachronous cancers were investigated. Results: 44 of 1048 patients with gastric cancer(4.1%) had synchronous and metachronous cancers. Of all 44 patients, 16 patients(36.4%) had synchronous cancer and 28 patients(63.6%) had metachronous cancers. The average time interval between gastric cancer and secondary primary cancer was 25.9 months. Most common another primary cancer was lung cancer(9/44, 20.5%), followed by colorectal cancer(8/44, 18.2%). Among 32 patients who had surgical resection for gastric cancer, 5 patients(15.6%) was synchronous group and 26 patients(83.9%) was metachronous group. Mean survival time of 44 patients was 49.3 months. Mean survival time was 22.4 months in synchronous cancer patients and 64.7 month in metachronous cancer patients. Mean survival time of patients who had surgical resection for gastric cancer was 57.8 months and who didn't have surgical resection for gastric cancer was 26.7 months. Conclusions: Because it is possible to extend the survival time by active surgical resection at the time of diagnosis in double cancer, we must pay attention to preoperative workup for synchronous cancer and postoperative follow-up for metachronous cancer in gastric cancer patients. Key words: gastric cancer, synchronous, metachronous