후두 편평세포암종에서 Galectin-1, 7의 발현 의의

Abstract

Background and Objectives : The role of different galectins in the pathogenesis of different types of malignancy is being profoundly investigated recently. In this study, the author investigated the level of galectin-1, 7 in the layngeal squamous cell carcinoma tissue to define its relationship to the tumor progression. Materials and Method : Paraffin-embedded tissue specimens from 77 patients, who were diagnosed as laryngeal squamous cell carcinoma from 1993 to 2007, were immunohistochemically stained for galectin-1, 7. Results : Galectin-1 expression was positively correlated with tumor stage and nodal involvement. Galectin-7 expression was increased in better differentiated tumors. Conclusion : Expression of galectin-1, 7 can be used as a valuable indicator in laryngeal squamous cell carcinoma under certain limitations.