백서에서 β-TCP와 이종 탈유기 골기질 이식재 이식이 골형성에 미치는 효과

Abstract

The purpose of this study was to evaluate the bone healing effect of grafting materials such as synthetic β-TCP (Bio-Oss), bovine bone derived HA (Cerasorb) and the mixture of β-TCP and HA in rats. Each type of samples was grafted in the frontal area of the prepared cranial bone defects (8mm) of 15 rats. The control group was performed without any grafting materials for 4 weeks and experimental three groups with grafting materials were conducted for 1, 2, 4 weeks. After implantation for 1, 2, 4 weeks, the rats were sacrificed for the histomorphometric studies using a light microscope and the observed data were analyzed by ANOVA. The results were as follows: 1. In all experimental groups, considerable inflammation and fibrosis were observed after 1, 2 weeks 2. However, in all experimental groups after 4 weeks, inflammation was reduced and fibrosis was stabilized. New bone formation was observed at the defect margin 3. Statistically, there was no considerable difference in new bone formation among the three experimental groups. It can be concluded that there is no considerable difference in new bone formation among the three grafting samples, such as Bio-Oss Cerasorb, and the mixture of Bio-Oss and Cerasorb.