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Investigation of Enantiomer Separation Using Chiral Crown Ethers as Chiral Selectors

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Author(s)
Wonjae Lee
Issued Date
2016
Keyword
Chiral Crown Ether Chiral Selector Chiral Stationary Phase 18-Crown-6-2,3,11,12-tetracarboxylic Acid Capillary Electrophoresis High-performance Liquid Chromatography
Abstract
A number of chiral selectors have been developed and applied for enantiomer separation of a variety of chiral compounds. Among these chiral selectors are chiral crown ethers, a class of synthetic host polyether molecules that bind protonated chiral primary amines with high selectivity and affinity. In this paper, two important chiral crown ethers as chiral selectors of bis-(1,1'-binaphthyl)-22-crown-6 and (18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) are focused. They have been widely used to resolve the enantiomers of chiral compounds containing a primary amino moiety using chiral stationary phases (CSPs) or chiral selectors by high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and so on in chirotechnology. Also, it was described that the commercially available covalent type HPLC CSPs derived from (+)- and (-)-18-C-6-TA have been developed and successfully applied for the resolution of various primary amino compounds including amino acids.
Publisher
조선대학교 기초과학연구원
Citation
Wonjae Lee. (2016). Investigation of Enantiomer Separation Using Chiral Crown Ethers as Chiral Selectors, 조선자연과학논문집 | Vol.9, No.1 p.28 ~ p.34
Type
Laboratory article
ISSN
2005-1042
URI
https://oak.chosun.ac.kr/handle/2020.oak/17301
http://www.chosun.ac.kr/user/indexSub.do?codyMenuSeq=24427455&siteId=ricns&dum=dum&boardId=175013&page=1&command=list&categoryId=266501&categoryDepth=0010
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2016 > Vol.9, No.1
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