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Molecular Docking Study of Novel Anti-Hepatitis B Virus Agents Isolated from Talaromyces Species

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Author(s)
Sathya Babu
Issued Date
2016
Keyword
Hepatitis B Virus Talaromyces Species Molecular Docking
Abstract
Hepatitis B virus is the leading source of liver disorders and is a global health problem and needs advancements in its treatment against increasing problems. Recently five vanitaracin derivatives were isolated from the fungus Talaromyces species which have anti-Hepatitis B virus activity. Hence, in the present study, molecular docking was carried out with five vanitaracin derivatives isolated from Talaromyces species and three known inhibitors.The objective of this work is to study the interaction of newly isolated compounds and compare its interaction with known inhibitors. The docking results revealed that vanitaracin derivatives have good interactions and has better docking score with the Hepatitis B virus and suggest SER2, SER4 and ASP30 are important residues involved in interaction with the inhibitors. These result authenticates vanitaracin derivatives contributes to inhibitory activity of Hepatitis B virus to treat liver disorders.
Publisher
조선대학교 기초과학연구원
Citation
Sathya Babu. (2016). Molecular Docking Study of Novel Anti-Hepatitis B Virus Agents Isolated from Talaromyces Species, 조선자연과학논문집 | Vol.9, No.1 p.23 ~ p.27
Type
Laboratory article
ISSN
2005-1042
URI
https://oak.chosun.ac.kr/handle/2020.oak/17300
http://www.chosun.ac.kr/user/indexSub.do?codyMenuSeq=24427455&siteId=ricns&dum=dum&boardId=175013&page=1&command=list&categoryId=266501&categoryDepth=0010
Appears in Collections:
2016 > Vol.9, No.1
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