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Molecular Docking Study of Urotension-2 Receptor (UTS2R)

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Author(s)
Sathya. B
Issued Date
2017
Keyword
UTS2R Molecular Docking
Abstract
Urotensin-2 receptor (UTS2R) is the most potent vasoconstrictor and plays a major role in the pathophysiology of various cardiovascular diseases and becomes a potential target for human pharmacotherapy. Hence, we have performed molecular docking of six antagonists with different inhibitory activity against UTS2R into its binding site. The binding mode of these antagonists was obtained using Surflex dock program interfaced in Sybyl-X2.0. The residues such as GLN278, THR304, TYR305, THR300, LEU299, CYS302, ASP47, TYR100 and THR304 are found in interaction between UTS2R and its antagonists. This study could be useful for identifying and analyzing the important residues involved in binding site of UTS2R receptor.
Publisher
조선대학교 기초과학연구원
Citation
Sathya. B. (2017). Molecular Docking Study of Urotension-2 Receptor (UTS2R), 조선자연과학논문집 | Vol.10, No.2 p.105 ~ p.109
Type
Laboratory article
ISSN
2005-1042
URI
https://oak.chosun.ac.kr/handle/2020.oak/17270
http://www.chosun.ac.kr/user/indexSub.do?codyMenuSeq=24427455&siteId=ricns&dum=dum&boardId=175013&page=1&command=list&categoryId=266502&categoryDepth=0011
Appears in Collections:
2017 > Vol.10, No.2
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