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Protein-protein Interaction Analysis of Bradykinin Receptor B2 with Bradykinin and Kallidin

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Author(s)
Santhosh Kumar Nagarajan Thirumurthy Madhavan
Issued Date
2017
Keyword
Bradykinin B2 Receptor GPCR Bradykinin Kallidin Peptide Modeling Protein-Protein Docking
Abstract
Bradykinin receptor B2 (B2R) is a GPCR protein which binds with the inflammatory mediator hormone bradkynin. Kallidin, a decapeptide, also signals through this receptor. B2R is crucial in the cross-talk between renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS) and in many processes including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Thus the structural study of the receptor becomes important. We have predicted the peptide structures of Bradykinin and Kallidin from their amino acid sequences and the structures were docked with the receptor structure. The results obtained from protein-protein docking could be helpful in studying the B2R structural features and in the pathophysiology in various diseases related to it.
Publisher
조선대학교 기초과학연구원
Citation
Santhosh Kumar Nagarajan. (2017). Protein-protein Interaction Analysis of Bradykinin Receptor B2 with Bradykinin and Kallidin, 조선자연과학논문집 | Vol.10, No.2 p.74 ~ p.77
Type
Laboratory article
ISSN
2005-1042
URI
https://oak.chosun.ac.kr/handle/2020.oak/17266
http://www.chosun.ac.kr/user/indexSub.do?codyMenuSeq=24427455&siteId=ricns&dum=dum&boardId=175013&page=1&command=list&categoryId=266502&categoryDepth=0011
Appears in Collections:
2017 > Vol.10, No.2
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