HIV 감염인의 치료순응도에 영향을 미치는 요인들에 관한 연구

Abstract

The purpose of the study was to explore the factors affecting antiretroviral therapy adherence of HIV-infected patients. For the study, the investigator interviewed 132 HIV-infected patients who medicated HAART(Highly Active Antiretroviral Therapy) at least over 6 months. And we reviewed their survey data on demographics factors(gender, age, married state, identity, education, employment, income level, living conditions), medical factors(period after the diagnosis, hospitalization experience, disability, number of CD4+T lymphocytes, taking period, frequency of taking doses per day, number of doses per day, side-effect, HIV drug resistance), medical service system factors(hospital accessibility, discomfortable hospital use, interrelationship with medical teams), and psychological factors(anxiety, depression, stigma, life satisfaction, self-efficacy, insight of the disease). And we measured antiretroviral therapy adherence using by the self-reported of adherence in the 1~3 months period. To analyze the antiretroviral therapy adherence and its affected factors. T-test, correlation analysis and stepwise regression analysis were used. The average age of 132 participants was 41.9 years, the rate of medication adherence was 86.52%. Stepwise regression analysis showed that, factors affecting antiretroviral therapy adherence of HIV-infected patients were significantly higher self-efficacy(p=.000), interrelationship with medical teams(p=.003), less frequency of taking per day(p=.001), higher recently number of CD4+T lymphocytes(p=.005), age(p=.010). The coefficient of determination(R²) was 33.8%. Through these analysis, the investigator found the relative importance of various factors affecting HIV patients' antiretroviral therapy adherence. The results of the study would provide an practically useful information for improving treatment adherence of HIV patients, and for developing more specialized treatment adherence program.