원인불명 호산구 증가증 환자에서 개회충증의 빈도와 임상양상에 대한 연구

Abstract

(Background) Toxocariosis is one of the causes of eosinophilia and eosinophilic infiltration in the various organs. Studies of the prevalance and clinical impact of toxocariasis in hypereosinophilia patients have been rare.

(Objective) The purpose is to evaluate the prevalence and clinical impact of toxocariasis in patients with unknown origin hypereosinophilia.

(Method) Patients with presenting with peripheral blood eosinophilia (＞500/μL or ≥10% of WBC) from July. 2010 through February. 2013 were enrolled. After rule out the medication histroy and the presence of allergic diseases, specific serum IgG antibiody to Toxocara canis larval antigen was measured by ELISA. At the same time, internal organ involvement was also evaluated.

(Result) One-hundred eleven patients were evaluated. Sixty nine patients (62%) were shown unknown origin hypereosinohilia, and forty five patients (65%) were diagnosed with toxocariasis. Treatment with albendazole with for unknown origin hypereosinophilia patients is highly effective.

(Conclusion) The prevalence of toxocariasis is high in patients with unknown origin hypereosinophilia. The toxocara ELISA is very impotant for evaluation of the cause of unknown origin hypereosinophilia.