갑상선 유두암종에서 RKIP, CK19, HBME1, NDRG1 및 p53 발현의 의미

Abstract

ABSTRACT

Significance of Expression of RKIP, CK19, HBME1, NDRG1, and p53 in Thyroid Papillary Carcinoma

Yun-Ju Han Advisor : Prof. Chae-Hong Suh, M.D. Ph.D Department of Medicine, Graduate School of Chosun University

Background : Raf-1 kinase inhibitory protein (RKIP) plays a role to determine tumor metastasis and it has been known as a prognostic marker in tumors. Cytokeretin 19 (CK19) has been identified to be useful to diagnose thyroid papillary carcinoma. HBME1, a marker in mesothelial cells, is helpful for diagnosis of malignant tumors. NDRG1 which is a member of the N-myc downstream regulated gene family. p53 has been reported to relate the clinical status or prognosis. This study aims to examine the significance between the expression of RKIP, CK19, HBME1, NDRG1 and p53 protein and clinicopathologic parameters in thyroid papillary carcinoma and analyze the correlation between RKIP, CK19, HBME1, NDRG1 and p53 expression. Material and Methods : This study performed the immunohistochemical staining for RKIP, CK19, HBME1, NDRG1 and p53 protein in 165 cases of thyroid papillary carcinoma. And this study examined the significance between expression of above antibodies and several clinicopathologic factors including age, sex, extra-thyroid extension, tumor size, lymph node metastasis, T stage, and multicentricity. Moreover, we analyzed the correlation between each expression of RKIP, CK19, HBME1, NDRG1 and p53 in thyroid papillary carcinoma. Result : In thyroid papillary carcinoma p53 expression was significantly associated with tumor multicentricity (p=0.026). RKIP expression showed the correlation with T stage (p=0.001). However, CK19, HBME1, and NDRG1 were not correlated with any other clinicopathologic parameters. Expression of RKIP showed the correlation between p53 protein (p=0.002) and HBME1 (p=0.043) respectively. And NDRG1 showed correlation with CK19 (p=0.017). Conclusions : These results demonstrated that the correlation between RKIP expression and T stage which suggest that may play some role tumor progression. Multicentricity in thyroid papillary carcinoma may be significant with p53 expression.