터비나핀의 발톱을 투과하는 약물 전달 시스템 개발

Abstract

Onychomycosis of finger nails and toenails is a disease caused by dermatophytes, fungi such as candida infections. Thus, the current antifungal oral formulation and a topical cream or spray formulation is used as treatment modality, but in order to prevent recurrence and complete treatment of disease, long term management of the time and cost required. So that patient compliance would be hampered. The purpose of this study was the development of transungual drug delivery system from pressure sensitive adhesive matrix containing terbinafine. The kinds of PSA matrix, effects of drug loading, various vehicles on the permeation of terbinafine from PSA matrix across porcine hoof membrane was evaluated using a plastic penetration chamber containing poloxamer 407 gel at 32 ◦C. Poloxamer 407 gel in the presence of terbinafine extract was analyzed quantitatively, different barrier composition of skin and nail were compared by permeability study. In addition, PPG 400, Triacetin, Propylene glycol, Transcutol®, Labrafil® 1944, NMP, DMSO, PEG 200, Hexylene glycol by incorporating in a non-acrylic and acrylic matrix showed good permeation enhancing effects. FT-IR study of porcine hooves membrane treated with various vehicles revealed that there is conformational change of keratin structure of nail.

Keyword : Onychomycosis; terbinafine; enhancer; pressure sensitive adhesive; porcine hoof.