일 대학병원 주요우울장애 입원환자의 항정신병약물 강화요법 경향

Abstract

ABSTRACT

The Patterns of antipsychotics Augmentation therapy in Inpatients with Major Depressive Disorder at a University hospital

Hyun Jang Advisor : Prof. Park Sang-Hag M.D. Ph.D Department of Medicine, Graduate School of Chosun University

Objectives The goal of this study was to examine the use of antipsychotics as antidepressant augmentation therapy and associating clinical factors in psychiatric inpatients with major depressive disorder at a university hospital.

Methods The participants in this study is the psychiatric inpatients with major depressive disorder at a University Hospital from 2007 until 2011. This retrospective chart review was conducted to determine the effectiveness of antipsychotics when given as antidepressant augmentation agents to inpatients with recurrent, treatment-resistant major depressive disorder (DSM-IV) and clinically associated factor that is sex, age, severity of depression, global assessment of functioning [GAF], past psychiatric history, suicidal idea, suicidal attempt, psychotic features were rated for each inpatient.

Results For augmentation treatment in the treatment of major depressive disorder, 26.9% of subject were used atypical antipsychotics. The most frequently used antipsychotics is risperidone(33.3%), quetiapine(20.4%), aripiprazole(18.5%), olanzapine(14.8%). The factor associated with choice of antipsychotics augmentation were sex(Male), Past psychiatric history, severity of depression, admission route(via OPD), psychotic features.

Conclusion The results of the present study show patterns of antipsychotics augmentation therapy for 5 years, from 2007 until 2011. The past psychiatric history, severity of depression, psychotic features, male, admission route(via OPD) was associated with augmentation therapy of antipsychotics in psychiatric inpatients. It mean that previous clinical research and other associating factors in clinical situation is important for antipsychotics augmentation therapy. Although limited by its design, this study suggests antipsychotic augmentation therapy in major depressive disorder may be a viable option in severe, recurrent or treatment-resistant major depressive disorder.

Key words : antipsychotics augmentation, Prescription pattern, Associated factor, Major depressive disorder