열공망막박리환자에서 유리체내의 PEDF

Abstract

ABSTRACT

Lee Young Chang Advisor : Prof. Choi Gwang-Ju, M.D. Department of Medicine, Graduate School of Chosun University

Purpose : To determine the vitreous and serum levels of pigment epithelium derived factor(PEDF) in rhegmatogenous retinal detachment (RRD) patients and to determine the relationship with the duration and involved quadrants of RRD. Methods : Vitreous fluid was collected from 25 eyes of 25 patients with RRD undergoing for vitrectomy and eighteen serum samples were also collected from of them. The concentration of PEDF in the vitreous and serum was investigated by enzyme-linked immunosorbent assay. Results : The mean concentration of PEDF was 3.36 ± 1.68 μg/ml(mean ± standard deviation) in 25 samples of the vitreous collected from RRD. It was higher than the mean concentration of 2.07± 1.29 μg/ml in 18 samples of the vitreous from the control (p > 0.05). The mean concentration of PEDF was 2.26 ± 0.92 μg/ml in 18 samples of the serum collected from the RRD patients. It was lower than the PEDF concentration of 2.64 ± 0.72 μg/ml in 18 samples of the serum collected from the control (p>0.05). The mean vitreous PEDF level ( 3.36 ± 1.68μg/ml) was significant higher than the serum level( 2.26 ± 0.92μg/ml) in the same 18 RRD patients. The duration of RRD was significantly correlated with the concentration of PEDF in vitreous(r=0.836, p<0.05). There was no significant correlation between the concentration of PEDF in vitreous and involved quadrants(r=0.288, p>0.05). Conclusions : The vitreous level of PEDF was significantly elevated in RRD patients. The duration of RRD was longer, the vitreous level of PEDF was higher.

Key Words : pigment epithelium derived factor(PEDF), Proliferative vitreoretinopathy, Rhegmatogenous retinal detachment