섬유근통에서 dense speckled pattern 항핵항체의 임상적 의미

Abstract

Background: Fibromyalgia(FMG) is a common disease characterized by chronic widespread pain and various manifestations. There has been reported high prevalence of psychologic distress, comorbidity, inflammatory autoimmune characteristics in patients with FMG. Despite of its high prevalence, there is still no standardized laboratory test to suggest FMG or its severity. Anti-dense fine speckled 70(Anti-DFS70) antibodies were initially identified as an anti-nuclear antibodies(ANA) from a patient with interstitial cystitis. Anti-DFS70 antibodies are found in 10% of healthy individuals, but only in a tiny population of with autoimmune rheumatic disease. These autoantibodies do not suggest any specific rheumatic disease. But there is no report in FMG patients.

Methods: It was based on the 39 fibromyalgia patients over the age of 20 who visited the Rheumatism, Internal Medicine Department of the Chosun University Hospital from August 2008 to January 2011 and for the disease comparison group of 17 systemic lupus erythematosus patients, for the normal comparison group of 19 healthy individuals who have not been diagnosed systemic autoimmune rheumatic disease and without diabetes mellitus, hypertension, dyslipidemia, cerebral infarction, cardiovascular disease, infectious disease and chronic disease like cancer. Especially for physical measurement like height, weight and BMI and disease duration, tender point, FIQ(Fibromyalgia Impact Questionnaire), VAS(Visual Analogue Scale), somatic symptom and anti-DFS70 antibodies were measured and the American college of rheumatology 1990 classification criteria of fibromyalgia was used to diagnose fibromyalgia.

Results: In this research, in the group with fibromyalgia patients group, systemic lupus erythematosus patients group and without systemic autoimmune rheumatic diseases group, they were evaluated for anti-DFS70 antibodies differences but statistically, between the three groups, there were no significant differences for anti-DFS70 antibodies and relativity between anti-DFS70 antibodies and age, height, weight, BMI, disease duration, tender point, FIQ(Fibromyalgia Impact Questionnaire), VAS(Visual Analogue Scale), and somatic symptom which were evaluated and statistically, they were confirmed to show the positive correlation between anti-DFS70 antibodies and VAS(Visual Analogue Scale).

Conclusion: The anti-DFS70 antibodies were found to show no significance in the diagnosing of the fibromyalgia but for the future, a large-scale research was seen as a necessity based on the confirmation that they were confirmed to show the positive correlation between anti-DFS70 antibodies and VAS(Visual Analogue Scale) which were thinked to be reflect clinically.

Key words : Fibromyalgia, anti-DFS70 antibodies