당뇨병이 없는 노인에서 당화혈색소와 심혈관질환 발생 위험인자의 상관관계

Abstract

Background: Glycosylated hemoglobin (HbA1c) is a useful index of mean blood glucose concentration over the preceding 2 to 3 months. Elevated HbA1C(>7%) are associated with a higher incidence of microvascular and macrovascular complications in patient with diabetes mellitus. But, the relationship between HbA1c and cardiovascular disease in non diabetic elderly population has been unclear. The aim of this study is to estimate the association of HbA1c with cardiovascular risk factor in non diabetic elderly population.

Method: The subject of this study included 1470 adults (816 males and 654 females) aged over 60 years who underwent regular health check-ups at the Health Promotion Center of Chosun University Hospital (Gwangju, Republic of Korea) from January 2009 to August 2010. Individuals previously diagnosed with diabetes, hypetension, or dyslipidemia and those treated with hypoglycemic agent, antihypertensive agent, and lipid lowering agent were excluded. After these exclusion, 370 adult (177 males and 193 females) were included in this study. We examined baseline HbA1c and cardiovascular risk factor.

Result: HbA1c revealed a significant correlation with fasting plasma glucose (r = 0.237, P = 0.000), triglyceride (r = 0.129, P = 0.013), LDL cholesterol (r = 0.107, P = 0.041), and HDL cholesterol (r = -0.160, P = 0.026). According to analysis by sex, HbA1c revealed a significant correlation with fasting plasma glucose (r = 0.307, P = 0.000), and LDL cholesterol (r = 0.207, P = 0.006) in male. However HbA1c revealed a significant correlation with fasting plasma glucose (r = 0.195, P = 0.027), and triglyceride (r = 0.147, P = 0.042) in female. Multiple regression analysis showed that HbA1c had a positive association with triglyceride, LDL cholesterol, and a negative association with HDL cholesterol.

Conclusion: The result of the present study demonstrated a significantly association between HbA1c and cardiovascular risk factor such as LDL cholesterol, triglyceride, and HDL cholesterol. The HbA1c level is correlated with cardiovascular risk factor in non diabetic elderly population and we suggest that HbA1c may predict cardiovascular risk as a useful tool in non diabetic elderly population.

Key words: HbA1c, cardiovascular risk factor, non diabetic elderly population