플라즈마 표면 개질된 키토산-젤라틴 고분자지지체

Abstract

Chitosan-gelatin formulations to be useful for tissue regeneration and clinical applications they must be biocompatible and possess favorable mechanical properties. Plasma surface modification can be used to improve the surface properties by creating functional groups to produce bioactive materials with different surface topography. In this study, chitosan-gelatin scaffolds were prepared via the freeze-drying technique. To improve cell proliferation, the scaffolds were then hydrophilized through plasma polymerization of acrylic acid (AAc) and allylamine (AAm). The chemical structure and morphology of chitosan-gelatin scaffold were investigated by ESCA, FTIR and SEM. Osteoblast like cell (MC3T3-E1) was seeded onto the prepared scaffolds in vitro to assess their biocompatibility. The AAc and AAm treated porous scaffolds were effective for cell proliferation, making them a suitable platform for tissue engineered applications.