전남, 광주 지역의 건강검진센터에서의 고요산혈증의 빈도와 임상적 의의

Abstract

Objective: This study was designed to identify the prevalence and clinical features of hyperuricemia in Gwangju and Jeonnam territory.

Methods: A total of 2309 subjects who received health examination in Chosun University hospital from January 2008 to June 2010 were enrolled in the study. All subjects are free from gout, diabetes, hypertension, rheumatoid arthritis, dyslipidemia, cerebral infarction, cardiovascular disease, cancer, asthma, and autoimmune disease. Hyperuricemia is defined as ≥7 mg/dl in men and ≥6 mg/dl in women. Metabolic syndrome is defined using IDF (International Diabetes Federation) criteria, revised at 2005. Clinical profiles were investigated including of age, waist circumference (WC), body mass index (BMI), fasting glucose, HbA1c, triglyceride, total cholesterol, HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), blood pressure (BP), high sensitivity-CRP (hs-CRP), homocysteine, fibrinogen, total bilirubin, gamma-glutamyl transferase (r-GT), aspartate aminotransferase/alanine aminotransferase (AST/ALT), alcohol drinking, smoking and excercise condition were investigated.

Results: The overall prevalence of hyperuricemia was 9.8%. The condition was more common in men than in women (14.9% vs 4.1%). Uric acid concentration has statistically significant correlation with WC, BMI, BP, triglyceride, total cholesterol, hs-CRP and r-GT (p<0.05). Additionally among men, uric acid concentration has significant correlation with WC. According uric acid concentration, the prevalence of metabolic syndrome is increased. Men with hyperuricemia had a 2.2-fold increasing risk of metabolic syndrome [odds ratio (OR)=2.224]. Women with hyperuricemia had a 2.8-fold increased risk of metabolic syndrome (OR=2.784) as compared with those without hyperuricemia.

Conclusion: The overall prevalence of hyperuricemia was 9.8%. The prevalence of metabolic syndrome is increased by increasing of uric acid concentration. Hyperuricemia is positive predictive factor for metabolic syndrome, that maybe has a role of risk factor.

Key words : Hyperuricemia, Metabolic syndrome, Cardiovascular disease