의식하 진정대장내시경 검사에서 미다졸람이 심폐기능에 미치는 영향

Abstract

ABSTRACT

Effect of midazolam on the cardiopulmonary function during conscious sedative colonoscopy

Kim Young Hoon Advisor : Prof. Park Chan-Kuk M.D., Ph.D Department of Medicine, Graduate School of Chosun University

(Background) The conscious sedation with midazolam has been shown to reduce anxiety and pain, to improve patient's tolerance and success rate of colonoscopic examination. Midazolam, however, sometimes leads to adverse effects such as the hypoxia and hypotension during examination. The aim of this study is to investigate the effects of midazolam on the cardiopulmoary function during conscious sedative colonoscopic examination.

(Method) Between February 2011 and September 2011, consecutive one hundred twenty six patients undergoing colonoscopy were divided into 2 group: (1) sedation with intravenous midazoloam (midazolam group:n=65); (2) no intravenous cannula(contol group:n=61). Peripheral oxygen saturation(SpO2), systolic and diastolic blood pressure and heart rate were recorded prior to, during and after the endoscopic procedure.

(Result) In medazolam group, the decrease of SBP and DBP from baseline was more significant during the colonoscopic procedure compared to those in control group. This decrease of SBP and DBP did not returned to normal range after the colonoscopic procedure. But, the frequency of SBP change in midazolam group was similar that in control group. In midazolam group, the decrease of HR and SpO2 from baseline was significantly lower in control group during colonoscopy. Although the decrase of HR did not return to the normal range, the decrase of SpO2 returned to the normal range after the colonoscopic procedure.

(Conclusion) This study showed that midazolam induced decrease of SBP, DBP, and peripheral oxygen saturation during colonoscopy exam. The clinically significant changes in SBP, heart rate and SpO2, however, was similar in midazolam and control group. These results may suggest that midazolam has a tolerable effect on the cardiopulmonary function and safely used during colonoscopy.

Key word : Colonoscopy, Midazolam. Cardiopulmonary function