성견에서 임프란트 주위에 골결손부를 형성한 후 이식재 크기에 따른 골형성에 관한 비교 연구

Abstract

ABSTRACT

Comparative study of bone regeneration in dog peri-implant defect on effect of different bone particle size

Baik, Sung-Mun Advisor : Prof. Kim, Su-Gwan Ph.D. Department of Oral and Maxillofacial Surgery Graduate School of Chosun University

Objectives. The aim of this study was to compare the efficacy of small particle sized TutoplastⓇ(particle size : 0.25~1mm) and large particle sized TutoplastⓇ (particle size : 1~2mm) for the regeneration of bone defects adjacent to titanium dental implants. Study design. In 6 mongrel dogs, 36 screw-typed RBM titanium dental implants were inserted in the dog's ilium. Bone defects were prepared in 6 mongrel dogs. (6 in each mongrel dog) Experimental groups were devided into 2 groups based on the size of the graft materials: Group 1 was garfted with small particles (particle size : 0.25~1mm) and group 2 was grafted with large particles (particle size : 1~2 mm). Before implantation, a standardized gap (2.15mm) was created between the implant surface and the surrounding bony walls by trephine bur (diameter 8 mm). The control group received no bone graft after implants placement. The gaps of experimental groups after implants (DentisⓇ, 𝚽3.7??10 mm) placement were filled the bone materials. The experimental groups were sacrificed at 2 different time points (4 and 8 weeks) for histomorphometric analysis. Results. New immature bone was observed at 4 and 8th weeks in the control and experimental groups. But lamellated new bone was observed at 8 weeks groups. The total volume of newly formed bone in defects with small particles was larger and more mature compared to defects with large particles after 4 and 8 weeks after implants placement. (p<0.05) In histomorphometric study, there was a statistically difference on new bone formation in defects between two groups (group 1, group 2) at 4,8 weeks after implants placement, but there was no a statistically significant difference on bone formation between two periods. (4 weeks, 8 weeks after implants placement) There was a statistically difference on new bone formation rates of implant threads between two groups (group 1, group 2) at 4,8 weeks after implants placement. (p<0.05) Conclusions. From the results of this study, we concluded that two different sized graft materials have positive effects on new bone formation. Additionally, smaller particles of grafting material has better influence on new bone formation.