골 전도 향상을 위한 나노 수산화인회석 코팅

Abstract

Hydroxyapatite (Ca10(PO4)6(OH)2, HAp) is materials mainly known for its special ability to contact bone tissue. Nanostructures on implant surfaces, a coating composed of nano-HAp particles on Ti, have aroused increasing research interest in the biomedical field. In this study, we prepared HAp nanocrystal coated Ti surface by plasma surface modification and wet chemical method and then evaluated biological behavior of MC3T3-E1 on the HAp coated on plasma modified Ti surface. Nano-size crystals of sintered HAp were uniformly coated on polyacrylic acid (PAA) deposited Ti surface through the ionic interaction between calcium ions on the HAp nanocrystal and carboxyl groups on the PAA/Ti. In vitro cell tests revealed surface modification of Ti surface with HAp nanocrystal significantly improved the adhesion and growth of the osteoblastic MC3T3-E1 cells and induced to differentiate at an enhanced level.