경구용 비스포스포네이트 관련 악골괴사의 진단 및 치료

Abstract

ABSTRACT Diagnosis and Treatment of Oral admidstrated Bisphosphonate-related osteonecrosis of the jaw

By Kyoung-Sup Yim Advisor : Prof. Seong-Yong Moon, D.D.S., M.D.S Department of Maxillofacial Surgery, Graduate School of Chosun University

Objectives: Bisphosphonates(BP) have been widely used for treatment of osteoporosis. Even though the efficacy of bisphosphonate, their administration may cause Bisphosphonate-related osteonecrosis of the jaw(BRONJ). The accurate incidence, pathogenesis and risk factor of BRONJ have not been clear and appropriate guidelines for prevention and treatment has not established. The objective of this clinical study is to provide accurate scientific information and to improve of clinicians’ approach about BRONJ. Methods: We evaluated BRONJ 30 patients taking oral BP because of osteoporosis visited Chosun University Dental Hospital from January 2008 to December 2010. All of them were female average age was 72.5. The mean duration of taking BP is 2.5 years accompanied by various systemic diseases. Occuring areas are 22 in the lower jaw, and 8 in the maxillary bone, primarily in the mandible were predominantly caused by trauma such as tooth extraction. Results: 2 cases of Stage 1, Stage 2 of the 27 cases, Stage 3 was classified 1 case. The result of treatment according to the step proces was improvement of symptoms in 22 cases, but 8 cases was not, so conservative treatment and surgical procedures were performed repeatedly. Conclusions: It is helped of patients understanding of the treatment that conversation about potential duration of treatment, insight of risk factors of osteonecrosis and precautions such as patients diagnosis. We must evaluate the potential states and another dangerous factor of osteonecrosis