전기유체역학과 압출유동시스템을 이용한 복합 세포 담체 제작에 관한 연구

Abstract

A hybrid technology that combines a 3D dispensing system and electrospinning processes for a 3D scaffold was used to produce a hierarchical 3D structure consisting of micro-sized polycarprolactone (PCL) strands and micro/nano-sized fibers. The micro/nanofiber biocomposite electrospun with PCL/small intestine submucosa (SIS) (8wt%) and PCL/silk (8wt%) was layered between the dispensed micro-strands. The scaffold including SIS showed higher hydrophilic property than other scaffolds due to the various hydrophilic components in SIS. The 3D hierarchical scaffold having biocomposites exhibited an incredibly enhanced initial cell attachment and proliferation of bone marrow stromal cells relative to normally designed 3D scaffolds.