비만아에서 소아 두통과 calcitonin gene-related peptide(CGRP)와의 관계

Abstract

Objective : Headache and obesity are both prevalent and often chronic conditions among children. Migraine pathophysiology is known that calcitonin gene-related peptide (CGRP) is an important postsynaptic mediator of trigemino-vascular inflammation. Plasma CGRP levels incresed in obese individuals. The purpose of this prospective study was to assess the relationship between headache and CGRP in obese children. Methods : I surveyed 33 patients who visited at Chosun University Hospital from March 2009 to September 2009. The CGRP level was compared between overweight and obese with headache group and overweight and obese without headache group. Headache was diagnosed by Revised International Headache Society criteria 2004 (IHS-R criteria 2004). Results : The data was collected from 33 patients (20 overweight and obese subjects without headache, 13 overweight and obese subjects with headache). Mean age was 12.3±2.3 (range 6-15 years). The mean CGRP level was 19.1±2.5 pg/ml in overweight and obese with headache group and 17.4±5.1 pg/ml in overweight and obese without headache group. The mean CGRP level in overweight and obese with headache group was not significantly higher than that in overweight and obese without headache group(P = 0.202). In under 19 pg/ml of CGRP level, mean headache frequency per month, mean severity and mean disability were 17.0±18.4, 4.0±2.8 and 2.0±0.0, respectively. In above and including 19 pg/ml of CGRP level, they were 11.0±9.8, 5.6±1.0, and 23.1±8.2, respectively. Conclusion: The mean CGRP level in overweight and obese children with headache was not significantly higher than in overweight and obese children without headache. There was no significant correlation between CGRP level and frequency, severity of headache and disability due to headache. Further studies are needed to access relationship of CGRP and pediatric headache in obesity.