플라즈마 중합반응으로 개질된 티타늄표면의 RGD 펩타이드의 고정화

Abstract

Plasma surface modification can be used to improve the surface properties of commercial pure Ti by creating functional groups to produce bioactive materials with different surface topography. In this study, a titanium surface was modified with acrylic acid (AA) using a plasma treatment and immobilized with bioactive arginine- glycine-aspartic acid (RGD) peptide, which may accelerate the tissue integration of bone implants. Both terminals containing the ?NH2 of RGD peptide sequence and ?COOH of AA thin film were combined with a covalent bond in the presence of 1-ethyl-3-3-dimethylaminopropylcarbodiimide(EDC). The chemical structure and morphology of PAA film and RGD modified surface were investigated by X-ray photoelectron spectroscopy (XPS), fourier transform infrared (FT-IR), atomic force microscopy (AFM), scanning electron microscopy (SEM). All chemical analysis showed full coverage of the Ti substrate with the PAA thin film containing COOH groups and the RGD peptide. This novel modified biocompatible surface highlight their potential as biocompatible implant materials.