광주 단일기관에서 최근 7년간 헬리코박터 파일로리 제균율 변화

Abstract

(Background) The standard triple therapy used as the first-line treatment for Helicobacter pylori infection are a combination of proton pump inhibitor(PPI), amoxicillin, and clarithromycin. The initial eradication rates of this combination therapy had been 90%. However, in recent studies the eradication rate has declined, and the adequate treatment of H. pylori is in question with insufficient questionable with insufficient studies. Therefore, this study evaluated the trend in the eradication rates of H. pylori infection over the last 7 years in the Gwang-ju area.

(Method) 258 patients diagnosed with H. pylori infection between January 2003 and December 2009 who received standard one-week triple regimen were retrospectively evaluated according to year, regimen, and ulcer locations.

(Result) The overall eradication rate was 81.8%. The decrease in eradication rate with first-line triple therapy over the study period was statistically significant (p<0.05). There was no difference in the eradication rate in patients with different underlying gastric diseases. Although the difference in eradication rate according to the proton pump inhibitor used was not statistically significant, the eradication rate for pantoprazole was lower compared to other proton pump inhibitors.

(Conclusion) The decrease in effectiveness of the recommended first-line therapy for H. pylori eradication in the last decade is statistically significant. Therefore, further studies and new guidelines should be discussed and changed in the near future.

Key word : Helicobacter pylori, Eradication rates