피부 기저세포암과 편평세포암의 면역조직화학적 차이

Abstract

Background : Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of skin are common tumor developed on sun-exposed area in old aged person. Of these, clinical outcomes showed slight difference in terms of invasiveness and metastasis. Therefore, differential diagnosis of two tumors is important to prognosis decision. Purpose: To investigate different characteristics between BCC and SCC, immunohistochemical staining for cytokeratin subtype, proliferation activity and invasion ability was performed. Materials and Method: Twenty five cases of BCC and SCC, respectively were collected. Immunohistochemical staining for cytokeratin (CK) 5/6, 7, 20, Ki-67, proliferatinf cell nyclear antigen(PCNA), and cathepsin B was done. Evaluation of positive cell rates was based on the percentage of positive tumor cells. Result: The average positive cell rates of SCC for CK5/6, CK7, CK20, Ki-67, PCNA and cathepsin B were 99%, 5.8%, 0%, 12.6%, 92.6% and 43.9%, respectively. The average positive cell rate of BCC for CK5/6, CK7, CK20, Ki-67, PCNA, and cathepsin B were 99%, 26.4%, 0%, 7.0%, 92.8%, and 72.9%, respectively. Statistically, positive cell rate for CK7 is higher in BCC rather than SCC (p=0.018). Cathepsin B showed higher positive cell rate in SCC than BCC (p=0.047). But there is no statistical difference for CK5/6, CK20, Ki-67, and PCNA between BCC and SCC. Conclusion: These results suggest that CK7 and cathepsin B are helpful markers for differentiation of BCC and SCC of the skin. Invasion ability is higher in SCC than BCC.