유기인계 살충제 중독 환자에서 생존군과 사망군의 비교 분석

Abstract

Background : The oranophosphate insecticide poisoning is going to be common and can be fatal. We compared the survivor and the dead patient in poisoning, and hope to be more helpful about a patient treatment.

Methods : 68 patients admitted to the hospital with acute organophosphate insecticide poisoning. We made a work sheet about the patient's ingestion time, amount, cause, vital sign, laboratory finding, antidote medication time, duration, and amount. Collected data were analysed and compared on the survivors and the dead peoples.

Results : There were statistically significance between the survivors and dead patients in mean age, alcohol intake state, typically expressed symptoms. And the dead patients had lower blood pressure, tachycardia, lower GCS score than the survivors. In blood gas analysis, dead patients were more acidemic and lowered saturations. Increased serum amylase level were found in dead patients. The survivors' initial and after 6-8 days followed serum cholinesterase activity were more significantly higher than the dead patients. And total amount of atropine which injected to patient were smaller in the survivors than the dead patients.

Conclusion: These results suggest that old patient who expressed typically intoxicated symptoms, lower GCS and blood pressure, shown acidosis in gas analysis, and low serum cholinesterase activity may be useful as a prognostic indicator in patients with organophosphate poisoning.

Key words :Organophosphate, cholinesterase, intoxication