비만인에서 운동요법이 골대사의 변화에 미치는 영향: 신체 계측, 대사 지표 및 Adipokines의 상관성

Abstract

ABSTRACT

Effect of Exercise on Bone Metabolism in Obese Young Adults: Correlations to Anthropometric Parameters, Metabolic Bio-markers, and Adipokines Jang Gook-Chan Advisor: Prof. Moon Kyung-Rye M.D., Ph.D. Department of Medicine Graduate School of Chosun University

Purpose : Although weight loss and exercise ameliorates metabolic complications in obese adults, the influence of exerciseon bone metabolism and mass is not clear. The aim of this study was to investigate the effect of exercise induced weight loss on bone metabolism and mass with various metabolic components in obese young adults. Methods : A total of 25 young adults (13 obese and 12 non-obese) were recruited in the public health center of Chosun University from January 1st to June 30th 2009. 8-weeks exercise training program (60-90min/day, 3days/week) was performed in all participants. We measured body compositions, serum lipid profiles, glucose, insulin, leptin, adiponectin, and bone markers (osteocalcin and c-terminal telopeptide of type Ⅰ collagen; ICTP) before and after exercise. Bone mineral content (BMC) and bone mineral density (BMD) of the lumbar spine, total hip, and proximal femur were measured before and after exercise.

Results : 1) Body weight (BW), BMI, body fat percentage, and visceral fat percentage were significantly decreased in control and obese group after exercise (P<0.05). 2) In metabolic bioolic biooserum insulin, HOMA-IR, ASToolic bLT levels were decreased in obese group than control group after exercise (P<0.05). 3) Before exercise, BMColic BMD on total hipolic trochanter were significantly increased in obese group than control group (P<0.05). Aic BMD on trochanter was significantly increased in obese group than control group after exercise (P<0.05). BMCoon trochanter was significantly increased in obese group after exercise than before (P<0.05). BMColic BMD of most areas in both group teicec to increase after exercise except lumbar spine. 4) Serum osteocalcin concentrations were significantly decreased in control and obese group after exercise (P<0.05). 5) Serum ICTP and leptin concentrations were significantly increased in obese than control group before exercise (P<0.05), but their diifired is were <0.0significant after exercise. 6) Serum leptin concentrations were significantly decreased after exercise in obese group after exercise (P<0.05). 7) Leptin/adiponectin ratio was significantly increased in obese than control groupoolic decreased in obese and control group after exercise. 8) In control groupoochangis of BW negatively correlwerdP<0.05changis of BMC(r=-0.929oolic r=-0.905) lic BMD(r=-0.929oor=-0.881) on total hip, and intertrochanter(P<0.05). Al i5changis of insulin negatively correlwerdP<0.05 BMCoon intertrochanter(r=-0.786 co<0.05). In obese groupoochangis of adiponectin ochantvely correlwerdP<0th BMC on femoral neck(r=0.629, P=0.028). And changes of HDL correlated with BMC on femoral neck (r=0.629) and trochanter(r=0.608)(P<0.05). Conclusion : BMC and BMD on some area in obese group compared to control group were increased before and after exercise. BMC and BMD on most areas in both groups tend to increase after exercise except lumbar spine. Weight loss with exercise and changes of insulin related to changes of BMC and/or BMD in control group. Changes of adiponectin and HDL correlated with changes of BMC in obese group. We need to further evaluation whether changes of leptin and bone markers after exercise may influence to bone mass in obese group.

Key Words : bone metabolism, exercise, obese young adults