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베타-3 아드레날린 수용체와 렙틴 수용체 유전자 다형성에 따른 대학생의 생화학 지표와 체성분 연구

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Author(s)
안명수
Issued Date
2009
Abstract
The purpose of this study was to investigate the body composition and biochemical parameters according to β-3 adrenergic receptor and leptin receptor polymorphism in university students. A survey was conducted with a total of 589 students - 231 males and 358 females. Based on a self-reporting method, the questionnaires were answered over 20 minutes, and β-3 adrenergic receptor, leptin receptor polymorphism and blood samples were also analyzed. The genotype frequencies of the β-3 adrenergic receptor polymorphism were Trp/Trp homozygote(73.0%) and Trp/Arg heterozygote(27.0%) in male students. For the female students, the distribution of genotypes was Trp/Trp(71.0%) and Trp/Arg(29.0%). The genotype frequencies of the leptin receptor polymorphism were Gln/Gln homozygote(57.9%) and Gln/Arg heterozygote(42.1%) in male students. For the female students, the distribution of genotypes was Gln/Gln(62.5%) and Gln/Arg(37.5%). There were no statistically significant differences according to biochemical parameters(AST, ALT, cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and hemoglobin) and body composition. When questioned if they were satisfied with their body shape, 30.3 and 37.7% of the male students answered they were 'satisfied' or needed to 'gain weight', respectively, whereas 18.5 and 76.5% of the female students answered they were 'satisfied' or needed to 'lose weight', respectively. Visceral fat was positively correlated with β-3 adrenergic receptor and leptin receptor polymorphism. β-3 adrenergic receptor polymorphism was positively correlated with body mass index, fat-free mass and visceral fat. In conclusion, this study found no significant effects in terms of β-3 adrenergic receptor and leptin polymorphism, but it is suggested that health-promoting education needs to be develop that female university students recognized their bodies appropriately and controlled their weight in desirable ways. Thus, it was recommended for them to have a health-promoting program to improve their healthy lifestyles.
Alternative Title
A study on body composition and biochemical parameters according to β-3 adrenergic receptor and leptin receptor polymorphism in university students
Alternative Author(s)
Ahn, Myoung Soo
Affiliation
광주삼성병원
Department
일반대학원 의학과
Advisor
장인엽
Awarded Date
2010-02
Table Of Contents
목 차
ABSTRACT․․․․․․․․․․․․․․․․․․․․․․․․․․․․ 1
I 서론․․․․․․․․․․․․․․․․․․․․․․․․․․․․ 3
제1절 연구의 필요성 및 목적․․․․․․․․․․․․․․․․․․․ 3
제2절 연구의 문제․․․․․․․․․․․․․․․․․․․․․․․․ 4
II 재료및 방법․․․․․․․․․․․․․․․․․․․․․․․․․․․․ 5
제1절 연구내용 및 방법․․․․․․․․․․․․․․․․․․․․․ 5
1.연구대상 및 조사기간․․․․․․․․․․․․․․․․․․․․ 5
2. 연구내용 및 방법․․․․․․․․․․․․․․․․․․․․․․ 5
가. 베타-3 아드레날린 수용체 유전자 다형분석․․․․․․․․ 5
나. 렙틴 수용체 유전자 다형 분석․․․․․․․․․․․․․․ 8
다. 공복 시 혈당, 간 효소 수치 및 혈청지질의 측정․․․․․․10
라. 신체계측에 의한 체성분 분석․․․․․․․․․․․․․․․10
마. 건강관련 생활습관․․․․․․․․․․․․․․․․․․․․10
3. 자료처리 및 통계분석․․․․․․․․․․․․․․․․․․․․10
III 결과․․․․․․․․․․․․․․․․․․․․․․․․․․․11
1. 베타-3 아드레날린 수용체와 렙틴 수용체 유전자 상대적 형질 빈도․․․․11
2. 공복 시 혈당, 간 효소 수치 및 혈당지질․․․․․․․․․․․11
3. 유전자 변이에 따른 체성분․․․․․․․․․․․․․․․․․15
4. 유전자와 체성분과의 상관관계․․․․․․․․․․․․․․․․18
5. 건강관련 생활습관․․․․․․․․․․․․․․․․․․․․․18
IV 고찰․․․․․․․․․․․․․․․․․․․․․․․․․․․21
1. 베타-3 아드레날린 수용체와 렙틴 유전자 상대적 형질 빈도․․․․․21
2. 공복 시 혈당, 간 효소 수치 및 혈당지질․․․․․․․․․․․22
3. 유전자 변이에 따른 체성분․․․․․․․․․․․․․․․․․22
4. 유전자와 체성분과의 상관관계․․․․․․․․․․․․․․․․25
5. 건강관련 생활습관․․․․․․․․․․․․․․․․․․․․․26
V 결론․․․․․․․․․․․․․․․․․․․․․․․․․․․․29
참고문헌․․․․․․․․․․․․․․․․․․․․․․․․․․․․․31
Degree
Doctor
Publisher
조선대학교
Citation
안명수. (2009). 베타-3 아드레날린 수용체와 렙틴 수용체 유전자 다형성에 따른 대학생의 생화학 지표와 체성분 연구.
Type
Dissertation
URI
https://oak.chosun.ac.kr/handle/2020.oak/8500
http://chosun.dcollection.net/common/orgView/200000239353
Appears in Collections:
General Graduate School > 4. Theses(Ph.D)
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