베타-3 아드레날린 수용체와 렙틴 수용체 유전자 다형성에 따른 대학생의 생화학 지표와 체성분 연구

Abstract

The purpose of this study was to investigate the body composition and biochemical parameters according to β-3 adrenergic receptor and leptin receptor polymorphism in university students. A survey was conducted with a total of 589 students - 231 males and 358 females. Based on a self-reporting method, the questionnaires were answered over 20 minutes, and β-3 adrenergic receptor, leptin receptor polymorphism and blood samples were also analyzed. The genotype frequencies of the β-3 adrenergic receptor polymorphism were Trp/Trp homozygote(73.0%) and Trp/Arg heterozygote(27.0%) in male students. For the female students, the distribution of genotypes was Trp/Trp(71.0%) and Trp/Arg(29.0%). The genotype frequencies of the leptin receptor polymorphism were Gln/Gln homozygote(57.9%) and Gln/Arg heterozygote(42.1%) in male students. For the female students, the distribution of genotypes was Gln/Gln(62.5%) and Gln/Arg(37.5%). There were no statistically significant differences according to biochemical parameters(AST, ALT, cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and hemoglobin) and body composition. When questioned if they were satisfied with their body shape, 30.3 and 37.7% of the male students answered they were 'satisfied' or needed to 'gain weight', respectively, whereas 18.5 and 76.5% of the female students answered they were 'satisfied' or needed to 'lose weight', respectively. Visceral fat was positively correlated with β-3 adrenergic receptor and leptin receptor polymorphism. β-3 adrenergic receptor polymorphism was positively correlated with body mass index, fat-free mass and visceral fat. In conclusion, this study found no significant effects in terms of β-3 adrenergic receptor and leptin polymorphism, but it is suggested that health-promoting education needs to be develop that female university students recognized their bodies appropriately and controlled their weight in desirable ways. Thus, it was recommended for them to have a health-promoting program to improve their healthy lifestyles.