구강암 세포주에 대한 고사리 추출물의 항암효과에 관한 연구
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Anti-cancer effects on oral cancer (KB) cells of extracts from Pteridium Aquilinum
Advisor: Prof. Seo, Jae Hong M.D., Ph.D.
Department of Alternative Medicine,
Graduate School of Health Science
Pteridium aquilinum has been used as a seasoned vegetables for a long time with us. The anticancer effects of extracts from Pteridium aquilinum on human oral cancer cells(KB cell line) were investigated in this study. Hot water extracts and methanol extracts from Pteridium aquilinum (HEPA, MEPA) were prepared and screened for their anti oral cancer activity by using MTS assay. HEPA in 24 h showed 82% of cell viability on 125 μg/ml, 76% on 250 μg/ml and 62% on 500 μg/ml. MEPA in 24 h showed 90% of cell viability on 125 μg/ml, 88% on 250 μg/ml and 70% on 500 μg/ml. And COX-2 protein expression was not inhibited by methanol extracts from Pteridium aquilinumwith using western blot analysis. These results showed that HEPA in 24 h was more significant than MEPA in 24 h.
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