성견에서 저강도파동형의 초음파가 신연골연장술에 미치는 효과

Abstract

ABSTRACT

Effects of low intensity pulsed ultrasound on distraction osteogenesis in dogs

Roh Yang Gyoon Advisor : Prof. Kim Byung-ock, Ph.D. Department of Dentistry, Graduate School of Chosun University

Distraction osteogenesis is a technique for reconstruction of skeletal deformities. The process involves gradual, controlled displacement of a surgical fracture resulting in simultaneous formation of new bone and expansion of adjacent soft tissue. This technique is a gradual bone lengthening that works with the body's natural healing mechanisms. Low intensity pulsed ultrasound (LIPUS) has been demonstrated to accelerate bone growth during orthopedic fracture healing. There is a lot of similarity between healing of bone fractures and distraction osteogenesis. There were six mongrel dogs included in the study. The dogs received a total of 12 distraction osteogenesis devices(Meditech, Gwangju, Korea), which were placed bilaterally into the mandibular premolar areas. LIPUS (IMPLASONIC, Dentis, Korea) treatment, 3.0 ㎒ and 240 ㎽/㎠, was conducted on the left premolar area for 15 minutes/day for seven days while the right side received no treatment. The dogs were sacrificed at four- and eight- weeks. Comparisons between the treatment and control groups were made using microcomputed tomography (micro-CT, Techvalley, Seongnam, Korea) and histologic analysis. Micro-CT analysis at both 4 weeks and 8 weeks, and histologic analysis at 8 weeks showed that the bone density and trabecular pattern had increased in the LIPUS treatment groups, but that bone volume did not increase in experimental group. Within the limited studies, the results indicated that LIPUS may have a positive effect on bone density and maturity but may have not affect bone volume. In the future, further research will be needed to the signal transmission associated with bone healing in cellular level.