제2형 당뇨병환자에서 대사증후군과 백혈구 수의 관계

Abstract

ABSTRACT

The Association Between White Blood Cell Count and Metabolic Syndrome in Type 2 Diabetes Mellitus

Park, Il-goo Advisor : Prof. Bae, Hak-yeon, M.D., Ph.D. Department of Medicine, Graduate School of Chosun University Aims : This study was performed to evaluate the association between WBC count and metabolic syndrome in Type 2 diabetic patients. Methods : 97 patients were enrolled. We defined the metabolic syndrome based on the NCEP/ATP III, while abdominal obesity was assessed based on the Asia-Pacific guidelines. The WBC, anthropometry, blood pressure, fasting glucose, insulin and lipid profiles were measured. Results : The prevalence of metabolic syndrome was 81.4% for total study subjects. The WBC counts increased with increasing number of components of metabolic syndorme. According to the quatiles of the WBC counts, the number of components of metabolic syndrome and percentage of patients with metabolic syndrome were increased in the highest WBC count quatile. WBC count had a positive correlation with BMI, blood pressure, triglyceride, glucse, insulin, and a negative correlation with a HDL-cholesterol. This results also increased with the number of Metabolic syndrome components (p<0.05 for trend). Conclusions : The WBC counts are associated with the metabolic syndrome in Type 2 Diabetes mellitus. This results suggest that metabolic syndrome may cause low-grade inflammation.

Key words : Metabolic syndrome, White blood cell count