실리콘을 기초로한 새로운 약물전달소재

Abstract

Optically encoded smart particles were prepared for noble drug delivery materials. Rugate porous silicon (PSi) was generated by applying a computer-generated pseudo-sinusoidal current waveform(1). This rugate PSi film was lift off from the Si substrate and thermally oxidized to convert PSi to porous silicon dioxide (PSD)(2). PSD film was derivatized with camptothecin (CPT)(3) and fractured by ultrasono-method to give smart particles(4). PSD smart particles exhibited a sharp photonic band gap in the optical reflectivity spectrum. Optical characteristic of PSD smart particles retained rugate photonic property in aqueous buffer solution. The release of CPT and change of reflection wavelength were measured by UV-vis and reflectance spectrometer, respectively. The intensity of differential peak from the smart particles is increased with a drug release. The blue shift of reflection peak resulted in the decrease of refractive index of PSD smart particles during the drug release. The concentration of released drug exhibited an exponential relationship with a release time and pH.