생쥐 피부에서 모낭 주기에 따른 MUDENG의 발현연구

Abstract

Cell death is a key pathway to remove the damaged cells, harmful cells, and unnecessary cells. Apoptosis is a well-defined type of cell death in terms of morphological changes and associated-known factors. Mu-2 related death-inducing gene (MUDENG) was found as an effort to identify an apoptosis-inducing factor. It has been shown that ectopic expression of MUDENG induces apoptosis in various cells including Jurkat T cells. To examine the role of MUDENG, the expression patterns of MUDENG in various mouse tissues using MUDENG monoclonal antibody were investigated by immunohistochemical staining. I found that MUDENG is expressed in most of tissues including intestine, immune system, lung, testis, ovary and skin. Especially in skin, MUDENG is highly expressed in sebaceous gland, some regions in outer root sheet but little or not in other cell types of hair follicle. Outer root sheath shows the different expression patterns in the stages of hair follicle. These results suggest that MUDENG plays a role in sebaceous gland metabolism and hair follicle cycle. Altogether MUDENG may take part in developing alopecia.