두경부 편평세포암종에서 PIN-1의 역할

Abstract

Multiple genetic and epigenetic events, including the aberrant expression and function of molecules regulating cell signaling, growth, survival, motility, angiogenesis, and cell cycle control, underlie the progressive acquisition of a malignant phenotype in squamous cell carcinomas of the head and neck (HNSCC). HNSCC is a malignant tumor of epithelial origin, which currently represents a major socio-sanitary problem since about 500,000 new cases are reported worldwide every year. HNSCC mortality is closely related to both local relapse and regional or distant lymphatic metastasis. However, any reliable tumor-specific biomarker to predict HNSCC prognosis is not currently available. The ability to understand the basic mechanism controlling inter- and intra-cellular communication has provided an unprecedented opportunity to understand how their dysregulation contributes to the growth and dissemination of human cancers. There are new tumor markers related to the metastatic spread that have not been yet evaluated in HNSCC. Pin-1 has been shown to regulate several phases of the cell cycle and is strikingly overexpressed in many human cancers. Here, the author will discuss the role of Pin-1 and interrelation between Pin-1 and VEGF, p53 protein or cyclin D1 on prognostic clinicopathologic parameters such as tumor differentiation, clinical stage and lymph node metastasis. The results can help elucidate their prognostic significances and the molecular mechanisms underlying HNSCC progression. ------------------------------------------------------- Key Words: Pin-1, VEGF, p53 protein, Cyclin D1, HNSCC