기능성 건강식품의 간질환 대사 및 대사증후군에 미치는 영향

Abstract

Insulin resistance is thought to play a central role in pathogenesis of NAFLD(nonalcoholic fatty liver disease), which considered a hepatic manifestation of the metabolic syndrome. Its prevalence is high in patients who have components of metabolic syndrome such as, central obesity, type 2 diabetes, hypertension and dyslipidemia. Some proportion of patients with NAFLD can progress to nonalcoholic steatohepatitis (NASH), characterized by hepatic inflammation and progressive fibrosis, ultimately leading to cirrhosis and end-stage liver disease. But the pathophysiological mechanism in this progression are poorly understood. Metabolic syndrome(MS) is characterized by insulin resistance accompanied by on or more of the following: obesity, hypertension, impaired glucose tolerance, low HDL-cholestero levels, and/or hypertriglyceridemia. Because each disease occurred in the same population and was the risk factor of athersclerosis and cardiovascular disease, they attract public attention. The important cause of insulin resistance which is a major pathophysiologic condition of MS was considered abdominal obesity. The purpose of this study was to understand and analyze the effect of functional food on metabolism of liver disease and metabolic syndrome. A total of 28 subjects, aged between 30 and 60 years, who visited the Samsung Hospital at Gwangju between April 2008 and August 2008 were studied. There were significant positive correlation of functional food with ALT, GGT, and ALP value. As well as a significant correlation was observed between functional food and serum total cholesterol and triglyceride level. BMI and glucose were not a significant correlations of functional food. In conclusion, functional food has effects on liver disease and may have effect on improving dyslipidemia. Further investigation about mechanism of and its effect on metabolic syndrome will be helpful in the management of metabolic syndrome and liver disease.