결장 직장 암에서의 VEGF의 발현

Abstract

Objective : The neovascularization is an essential a factor for the growth of solid organ cancer, and especially vascular endothelial growth factor (VEGF) has been known to the very important mediator of neovascularization. Thus, this study was searching that expression of VEGF in colorectal cancer correlate to clinicopathologic factors. Methods : 93 patients were collected from the patients who underwent sporadic colorectal cancer and they studied immunohistochemistry at Chosun University hospital from March, 2002 to November, 2005. Results : The expression rate of VEGF was 61 cases of all (65.6%). There were no significant relation VEGF expression to age, sex and lymph node metastasis. But, VEGF expression in colon cancer was 80.5% better than 53.8% in rectal cancer (P = 0.010). Correlation with T staging, expression of VEGF was 10.0% in pT0, 62.5% in pT1, pT2 and 77.2% in pT3, pT4 (P<0.0001), and correlation with TNM staging, expression of VEGF was 10.0% in stage 0, 63.2 in stage I, 72.0% in stage II, 73.3% in stage III and 100.0% in stage IV (P=0.001). Conclusion : Expression of VEGF in colorectal cancer was closely relationship with cancer progression, and more expressed in colon than rectal cancer. These results were suggested that target therapy targeting VEGF may be more benefit for the treatment of advanced colon cancer. Key Words : Target therapy, VEGF, Colorectal cancer