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배양망막색소상피세포에서 산화성스트레스에 의한 IL-8의 발현변화

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Author(s)
허준
Issued Date
2008
Keyword
Interleukin-8|Monocyte chemoattractant protein-1|N-acetylcys teine|Oxidativestress|Paraquat
Abstract
Purpose: To evaluate the expression of Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in the cultured ARPE-19 cells.
Methods: ARPE-19 cells were exposed to paraquat for 72 hours and then assayed for mRNA expression of IL-8 and MCP-1 by reverse transcription polymerase chain reaction method. And the effect of antioxidant, N-acetyl cysteine (NAC) on the oxidative stressed - ARPE-19 cells was measured.
Results: IL-8 expression was increased in the oxidative stress group compared with the control, but the increase of expression was blocked by mixing NAC with paraquat.
Conclusion: Oxidative stress stimulates IL-8 expression in the cultured human retinal pigment epithelial cells, which could be helpful to understand the mechanism of neovascularization in age-related macular degeneration.
Alternative Title
Expression of IL-8 in cultured ARPE-19 cells under the oxidative stress
Alternative Author(s)
Heo, Jun
Affiliation
조선대학교 대학원 의학과
Department
일반대학원 의학과
Advisor
지남철
Awarded Date
2008-08
Table Of Contents
1.서론 = 1
2.연구대상 및 방법 = 2
3.결과 = 4
4.고찰 = 5
5.참고문헌 = 7
Degree
Master
Publisher
조선대학교 대학원
Citation
허준. (2008). 배양망막색소상피세포에서 산화성스트레스에 의한 IL-8의 발현변화.
Type
Dissertation
URI
https://oak.chosun.ac.kr/handle/2020.oak/7313
http://chosun.dcollection.net/common/orgView/200000236572
Appears in Collections:
General Graduate School > 3. Theses(Master)
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