Povidone-Iodine 용액의 적용 시간에 따른 타액 내 세균수의 비교

Abstract

Since numberless bacteria lives in the oral cavity, there has not been developed yet about complete sterilizing disinfection of oral cavity. There is some difference between each clinics about oral antiseptic agents and methods using in oromaxillofacial surgery however, the reality about antiseptic is that it used to be proceeded just as the past without any verification. The purpose of this study was to compare the effect of different application time of povidone-iodine solution on salivary bacterial counts. The study was performed with 20 persons (10 males, 10 females) between the age of 26 and 32 who didn’t have any systemic disease and didn't take any medicine in recent 3 months. 2.5mL of non-stimulatory saliva was first collected from every subjective persons. Then, 2.5mL of saliva after rinsing for 1 minute with povidone-iodine solution was collected from 10 persons (5 males and 5 females) of group 1 and 2.5mL of saliva after rinsing for 2 minute with povidone-iodine solution was collected from 10 patients(5 males and 5 females) of group 2. These samples were cultured for 48 hours aerobically. The colony-forming units (CFU) were calculated for each time point and reduction rate of CFU between 2 groups were tested using ANOVA. Both groups showed significant decrease on CFU according to applied times (P<0.01). But, the percentage of decrement of CFU between 2 groups was not shown statistically significant difference. The present study confirmed that povidone-iodine was excellent oral antiseptic agent. And there was no significant difference on the reduction rate of salivary bacterial counts in regard to its application time, 1 and 2 minutes.