후두 편평세포암종에서 Galectin-3과 Pim-1의 발현

Abstract

To assess the significance of Galectins and Pim-1 protein in larynx tumors and their correlation with prognostic factors, samples from 77 patients with squamous cell carcinomas of larynx were studied immunohistochemically. In the present study, the author examined the correlations of Galectin-3 and Pim-1 protein expression according to tumor stages, nodal status, clinical stages and histologic differentiation to investigate the clinical significance. Squamous cell carcinoma showed increased Galectin-3 and Pim-1 expression in more advanced stage, tumor stage and nodal status. So it was suspected that the pathogenetic role of Galectin-3 and Pim-1 expression in laryngeal squamous cell carcinoma. And it indicates that Galectin-3 and Pim-1 can be used as a possible prognostic factor.