안트라피라졸 고분자의 합성 및 형과 특성

Abstract

Activation of the JNK pathway has been documented in a number of disease setting, providing the rationale for targeting this pathway for discovery. In addition, molecular genetic approaches have validated the pathogenic role of this pathway in several diseases. Anthrapyrazolone compounds have been used as a drug for treatment of the disease relating to the Jun N-terminal Kinase pathway such as autoimmune and inflammatory disease. They include rheumatoid arthritis, asthma, inflammatory, bowel disease, multiple sclerosis, cardiovascular disease etc. The Jun N-terminal Kinase(JNK) pathway is activated by exposure of cells to environmental stress or by treatment of cells with pro-inflammatory cytokines. argets of the jnk pathway include the transcription factors c-jun and ATF2. hese transcription factors are members of the basic leucine zipper group that bind as homo and hetro-dimeric complexes to AP-1 and AP-1-like sites in the promoters of many genes. In this study the polymerization of anthrapyrazolone-containing monomer is proposed to reduce the toxicity of the drug. also its luminescence characteristics has beech studied since it has conjugated structure and large cross section of chromophore.