수영운동이 뇌출혈 흰쥐의 단기기억능력과 세포생성에 미치는 영향

Abstract

Intracerebral hemorrhage is one of the most devastating types of stroke. It is known to cause severe neurological damage and is also associated with a very high mortality rate. In the present study, we investigated the effects of swimming exercise on short-term memory and apoptotic neuronal cell death in the striatum following intracerebral hemorrhage in rats. Intracerebral hemorrhage was induced by the injection of collagenase into the striatum using a stereotaxic instrument. The animals in the swimming groups were forced to swim for 30 min once daily for ten consecutive days. The present results showed that lesion size and apoptotic neuronal cell death in the striatum were significantly increased following intrastriatal hemorrhage and that swimming exercise reduced the size of the hemorrhage-induced lesions and inhibited apoptotic neuronal cell death in the striatum. Swimming exercise also suppressed the intrastriatal hemorrhage-induced cell proliferation in the dentate gyrus, which is a compensatory response to the excessive neuronal cell death induced by hemorrhage. Here in this study, we demonstrated that swimming exercise overcomes intracerebral hemorrhage-induced apoptotic neuronal cell death and thus facilitates recovery following intracerebral hemorrhage.