대두 이소플라본섭취가 골결핍증을 보이는 젊은 여성의 골밀도에 미치는 영향

Abstract

ABSTRACT

Effect of soy isoflavone supplementation on bone mineral density in young women with osteopenia

Eun Jeong Advisor : Prof. Ro, Hee-Kyung, Ph. D. Department of Food and Nutrition, Graduate School of Chosun University

This study was conducted to investigate effects of soy isoflavone supplementation on bone mineral density in 36 young females with osteopenia for 12 weeks. Subjects were divided into three groups on the criteria of status of bone mineral density. The experimental groups were supplemented with either 80mg of isoflavone[Iso-80] or 40mg of isoflavone[Iso-40]. To placebo group 40mg of powdered glutinous rice was administrated. It was found that many subjects with osteopenia had higher percent body fat and lower activity level compared to control group. There was no significant difference in serum osteocalcin concentration between Iso-40 and placebo group, but significant differences in osteocalcin concentration were shown between Iso-80 and placebo group. BQI was positively correlated with mineral content, lean body mass, muscular mass and blood components such as albumin, Ca, Mg, ALPase and osteocalcin. Both Iso-40 and Iso-80 supplementation for 12 weeks significantly increased protein and mineral content in the body. Supplementation of isoflavone was more effective to control total cholesterol and LDL-cholesterol compared to placebo group. Furthermore, there were significant differences in potential variations in blood Ca concentration and osteocalcin among Iso-40, Iso-80 and placebo group after the experiment. The results suggested that body fat rather than body weight is a major contributor to lead to lower bone mineral density in young females. Since lower intakes of Ca and folate were noted in the subjects emphasis should be given to adequate intakes of these nutrients in the subjects. Conclusively, 12 week isoflavone supplementation in young females with osteopenia had positive effects on bone mineral density and bone turnover marker, contributing to higher bone mineral density and lower blood mineral concentrations.