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필라델피아 음성 만성골수증식성질환의 임상고찰

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Author(s)
하재화
Issued Date
2007
Keyword
필라델피아|만성골수증식성질환|클론성 질환|혈관협병증|골수세포
Abstract
Background : Philadephia chronosome negative chronic myeloproliferative disorde(CMPD) is a clonal disorder which includes polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis. CMPD has chronic course and different clinical features. Especially CMPD accompany vascular complications. We evaluated the clinical features, complications, treatment and effect of treatment of CMPD
Methods : We retrospectively reviewed the medical records of patients with CMPD between December 2002 and December 2006.
Result : Eighteen patients were identified. The mean age of 18 CMPD patients was 64 years(range, 40-83) and male to female ratio was 1:2. Clinical manifestations were abdominal discomfort(22%), aquagenic pruritis(22%), skin phletora(22%), bleeding(16%), thrombosis(11%) and dizziness(11%). Treatment with hydrea was most frequent during clinical course of CMPD. Complication of disease itself and treatment was not frequent except bleeding and thrombotic event. Conversion to acute leukemia was none.
Conclusions : CMPD is a chronic disease and desirable effect result from DNA biosynthesis inhibitor and cyclic nucleotide phosphodiesterase inhibitor.
Alternative Title
Clinical analysis of Ph(-) chronic myeloproliferative disorder
Alternative Author(s)
Ha, Jae-Hwa
Affiliation
조선대학교 대학원
Department
일반대학원 의학
Advisor
박치영
Awarded Date
2007-08
Table Of Contents
ABSTRACT = 4
Ⅰ. 서론 = 6
Ⅱ. 대상과 방법 = 8
Ⅲ. 결과 = 9
Ⅳ. 고찰 = 12
Ⅴ. 결론 = 16
참고문헌 = 20
Degree
Master
Publisher
조선대학교 대학원
Citation
하재화. (2007). 필라델피아 음성 만성골수증식성질환의 임상고찰.
Type
Dissertation
URI
https://oak.chosun.ac.kr/handle/2020.oak/6934
http://chosun.dcollection.net/common/orgView/200000234496
Appears in Collections:
General Graduate School > 3. Theses(Master)
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