가토 두개골 결손부에서 비흡수성 차단막의 유지 기간에 따른 골조직 형성효과

Abstract

When clinicians faced with an insufficient volume of supporting bone on ideally esthetic and biomechanical position for dental implantation, guided bone regeneration(GBR) was indicated. Although GBR has wide application at clinic, proper time of membrane removal remains qustionable in using non-resorbable membrane, such as non-expanded polytetrafluoroethylene(PTFE). The aim of this study was to compare the effect on bone regeneration relative to maintenance period of PTFE membrane in rabbit calcarial defects. Eight adult New Zealand white female rabbits were used in this study. Four defects were surgically made in their calvaria. Using a trephine bur, 4 'through and through' defects were created and classified into 3 groups, which were consisted of control group(no graft), experimental group 1(autogenous bone)and experimental group 2(deproteinized bovine bone; OCS-B^(ⓡ)). The defects were covered with PTFE membrane(Cytoplast^(ⓡ)). Membranes were removed after 1, 2, 4 and 8 weeks post-GBR in each 2 rabbits. And then, all rabbits were sacrificed, specimens were taken and observed histologically. The results were as follow; 1) The use of graft material and membrane was necessary in GBR procedure. 2) When PTFE membranes were removed early, the most favorable bone regeneration was revealed in experimental group I, followed by experimental group II and control group. 3) On GBR, it is recommended that membrane should maintain for 4 weeks with autogenous graft. As well, the use of xenograft need longer maintenance period than autogenous bone. Further evaluations were required, such as histochemical reserch, more species and different grafting materials. And on the basis of these studies, clinical researches were required.