한방 추출물을 이용한 속붕해성 제형의 개발

Abstract

The fast disintegrating tablet (FDT) containing oriental herbal medicine was prepared by using a freeze-drying method. To improve taste and morphology of FDT crosslinked povidone was added to FDT. To study the effect of excipients on FDT, mechanical strength and disintegration time of FDT were measured. The mechanical strength of FDT was increased by adding excipients. Especially, kollidon CL-M suppressed a bitter taste of SYT. Microscopic structure of the resulting freeze-dried solid dosage form was observed by using a optical microscope. The microscopic structure of FDT was very porous after freeze drying. As a result of porous structure of FDT manufactured by freeze drying method, the disintegration time of FDT was less than 30 seconds in volunteer's oral cavity. The mechanical strength of the FDT was measured using specially designed apparatus. The mechanical strength measurement indicated that the mechanical strength of FDT was significantly higher than commercialized FDT by freeze-drying method.