전자간증에서 혈액검사 변화에 대한 고찰

Abstract

Background : Pre-eclampsia is a pregnancy-specific syndrome of reduced organ perfusion secondary to vasospasm and endothelial activation and threatens the life of both mother and fetus. Thrombocytopenia is characteristic of worsening pre-eclampsia and plays a major role in the pathogenesis of pre-eclampsia. The aim of this study is to compare the complete blood count(CBC) parameters include platelet count, in pre-eclamptic and normal pregnant women for evaluate whether these parameters have a statistically difference between two groups and a application in differential diagnosis for other pregnancy induced hematologic change. Methods : The subjects consist of 70 pre-eclamptic and 71 normal pregnant women for control group between January 2003 and March 2006, retrospectively. Preceding medical histories of all patients were normal. Pre-eclampsia was defined as the onset of hypertension(blood pressure of 140/90 mmHg or greater, 6 h or more apart) and consistent proteinuria (300 mg/day or more) during the latter half of the pregnancy with both remitting remotely after delivery. Blood sampling was done during third trimester before delivery. Result : There was no statistically significant difference according to CBC including platelet count when pre-eclamptic patients were compared with controls. Conclusions : A normal pregnancy causes numerous changes to occur in all organs of the body including the following hematologic findings; physiologic anemia, neutrophilia, mild thrombocytopenia, increased procoagulant factors, and diminished fibrinolysis. This study was to identify statistically significant changes occuring in the hematologic findings of a preeclampsia patient compared with that of a normal pregnancy. Thrombocytopenia of 15-50% occurring in a preeclampsia patient and in HELLP syndrome, a severe variant of preeclampsia, led to the question of availability of the platelet counts as a prognostic index. In this study, although there were 17 patients with thrombocytopenic findings in the preeclampsia group, there were no statistically significant differences compared to the normal group in complete blood count including platelet count. The diverse reports of previous studies concerning the platelet counts and mean platelet volume of preeclampsia pregnancies along with this study requires a larger study to be taken place in the future.